Targeting metastatic upper gastrointestinal adenocarcinomas
نویسندگان
چکیده
منابع مشابه
Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas.
DNA amplification at 17q is frequently detected in upper gastrointestinal adenocarcinomas (UGC; stomach and esophagus). In this study, we did fluorescence in situ hybridization on a tissue microarray that contained 304 UGCs and 89 normal stomach samples using a approximately 168-kb BAC clone (CTD-2019C10) that maps to 17q12-q21.1. This 168-kb region contains the following genes: PPP1R1B/DARPP-3...
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Cofactor of BRCA1 (COBRA1) is a newly characterized member of the negative elongation factor (NELF) complex. In this work, we show that COBRA1 is overexpressed in the majority of primary upper gastrointestinal adenocarcinomas (UGC), and its overexpression correlates with down-regulation of TFF1. We have detected overexpression of COBRA1 mRNA using quantitative real-time reverse transcription-PC...
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ژورنال
عنوان ژورنال: World Journal of Clinical Oncology
سال: 2011
ISSN: 2218-4333
DOI: 10.5306/wjco.v2.i3.135